A microfluidic approach for high-throughput droplet interface bilayer (DIB) formation | Zendy

Claire E. Stanley | Zendy; Katherine S. Elvira | Zendy; Xize Niu | Zendy; Antony D. Gee | Zendy; Oscar Ces | Zendy; Joshua B. Edel | Zendy; Andrew J. deMello | Zendy

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A microfluidic approach for high-throughput droplet interface bilayer (DIB) formation

Author(s) -

Claire E. Stanley,

Katherine S. Elvira,

Xize Niu,

Antony D. Gee,

Oscar Ces,

Joshua B. Edel,

Andrew J. deMello

Publication year - 2010

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/b924897h

Subject(s) - microfluidics , throughput , bilayer , interface (matter) , flexibility (engineering) , nanotechnology , lipid bilayer , phosphocholine , materials science , chemistry , computer science , pulmonary surfactant , membrane , phospholipid , phosphatidylcholine , biochemistry , gibbs isotherm , statistics , mathematics , wireless , telecommunications

We present a simple, automated method for high-throughput formation of droplet interface bilayers (DIBs) in a microfluidic device. We can form complex DIB networks that are able to fill predefined three dimensional architectures. Moreover, we demonstrate the flexibility of the system by using a variety of lipids including 1,2-diphytanoyl-sn-glycero-3-phosphocholine (DPhPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).

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