Open AccessA glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins
Author(s) -
Joana Marques,
Teresa M. Santos,
M. Paula M. Marques,
Susana S. Braga
Publication year - 2009
Publication title -
dalton transactions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.98
H-Index - 184
eISSN - 1477-9234
pISSN - 1477-9226
DOI - 10.1039/b915839a
Subject(s) - thermogravimetric analysis , chemistry , stoichiometry , ruthenium , fourier transform infrared spectroscopy , nuclear chemistry , cyclodextrin , glycine , proton nmr , stereochemistry , polymer chemistry , organic chemistry , catalysis , amino acid , biochemistry , chemical engineering , engineering
The complex Ru([9]aneS(3))(gly)Cl (gly = glycine) was obtained from the reaction of the precursor Ru([9]aneS(3))dmsoCl(2) with glycine and encapsulated into native beta-CD, a hydroxypropylated derivative HPbetaCD, and the methylated cyclodextrins TRIMEB and CRYSMEB. All four inclusion compounds were obtained with a 1:1 host:guest stoichiometry and characterised in the solid-state by powder X-ray diffraction, thermogravimetric analysis (TGA), and (13)C{(1)H} CP/MAS NMR and FTIR spectroscopies. The cytostatic and antiproliferative activity of the complex Ru([9]aneS(3))(gly)Cl and its four CD inclusion compounds was tested on the human osteosarcoma MG-63 cell line and the results compared to the inhibitory effect exerted by the pure cyclodextrins.
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