The spore photoproduct lyase repairs the 5S- and not the 5R-configured spore photoproduct DNA lesion | Zendy

Marcus G. Friedel | Zendy; Olivier Berteau | Zendy; J. Carsten Pieck | Zendy; Mohamed Atta | Zendy; Sandrine Ollagnier de Choudens | Zendy; Marc Fontecave | Zendy; Thomas Carell | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The spore photoproduct lyase repairs the 5S- and not the 5R-configured spore photoproduct DNA lesion

Author(s) -

Marcus G. Friedel,

Olivier Berteau,

J. Carsten Pieck,

Mohamed Atta,

Sandrine Ollagnier de Choudens,

Marc Fontecave,

Thomas Carell

Publication year - 2005

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/b514103f

Subject(s) - spore , dna , chemistry , lesion , photochemistry , biology , microbiology and biotechnology , biochemistry , medicine , psychiatry

The spore photoproduct lyase is a Fe-S/AdoMet DNA repair enzyme, which directly repairs spore lesions, induced by UV irradiation of spores, using an unknown radical mechanism. The air sensitive radical SAM enzyme was for the first time challenged with synthetically pure substrates. It was found that the enzyme recognizes a synthetic 5S-configured spore lesion without the central phosphodiester bond. The 5R-configured lesion is in contrast to current belief not a substrate.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research