Advances in glycoprotein synthesis
Author(s) -
Lei Liu,
Clay S. Bennett,
ChiHuey Wong
Publication year - 2005
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/b513165k
Subject(s) - glycoprotein , glycopeptide , native chemical ligation , homogeneous , chemistry , biochemistry , in vivo , computational biology , in vitro , biology , chemical synthesis , microbiology and biotechnology , physics , thermodynamics , antibiotics
The development of chemical and enzymatic methods for the synthesis of homogeneous glycoproteins is a fascinating challenge at the interface between chemistry and biology. Discussed here are the currently available methods for preparation of homogeneous glycoproteins. These methods include (1) glycopeptide ligation; (2) glycoprotein remodeling; and (3) in vivo suppressor tRNA technology.
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