Enantioselective epoxidation of linolenic acid catalysed by cytochrome P450BM3 from Bacillus megaterium | Zendy

Ayhan Çelik | Zendy; Davide Sperandio | Zendy; Robert Speight | Zendy; Nicholas J. Turner | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Enantioselective epoxidation of linolenic acid catalysed by cytochrome P450BM3 from Bacillus megaterium

Author(s) -

Ayhan Çelik,

Davide Sperandio,

Robert Speight,

Nicholas J. Turner

Publication year - 2005

Publication title -

organic and biomolecular chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.923

H-Index - 146

eISSN - 1477-0539

pISSN - 1477-0520

DOI - 10.1039/b506155e

Subject(s) - bacillus megaterium , chemistry , enantioselective synthesis , selectivity , catalysis , cytochrome , organic chemistry , stereochemistry , enzyme , bacteria , genetics , biology

Cytochrome P450(BM3), from Bacillus megaterium, catalyses the epoxidation of linolenic acid yielding 15,16-epoxyoctadeca-9,12-dienoic acid with complete regio- and moderate enantio-selectivity (60% ee). The absolute configuration of the product is tentatively assigned as 15(R),16(S)-. The Michaelis-Menten parameters kcat and Km for the reaction were determined to be 3126 +/- 226 min(-1) and 24 +/- 6 microM respectively.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research