Synthesis and analysis of peptide nucleic acid oligomers using Fmoc/acyl-protected monomers | Zendy

Györgyi Kovács | Zendy; Zoltán Tímár | Zendy; Zoltán Kupihár | Zendy; Zoltán Kele | Zendy; Lajos Kovács | Zendy

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Synthesis and analysis of peptide nucleic acid oligomers using Fmoc/acyl-protected monomers

Author(s) -

Györgyi Kovács,

Zoltán Tímár,

Zoltán Kupihár,

Zoltán Kele,

Lajos Kovács

Publication year - 2002

Publication title -

journal of the chemical society perkin transactions 1

Language(s) - English

Resource type - Journals

eISSN - 1472-7781

pISSN - 1364-5463

DOI - 10.1039/b201297a

Subject(s) - oligomer , monomer , chemistry , nucleic acid , peptide synthesis , solid phase synthesis , peptide , combinatorial chemistry , peptide nucleic acid , high performance liquid chromatography , organic chemistry , polymer chemistry , polymer , biochemistry

The optimization of PNA oligomer synthesis has been accomplished employing Fmoc/acyl-protected monomers on TentaGel™ and Wang resins. Among the tested activating agents (CMP, BET, HATU) the latter was of choice in solid phase syntheses. “Leakage” of TentaGel™ resin greatly hampers the solution and MS analyses. Synthesis and acyl group deprotection steps have been separately examined using Wang resin. Optimal conditions also worked well on the CPG support. HPLC and MS analyses of the PNA oligomers were carried out under various conditions.

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