Open AccessReversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A
Author(s) -
Matthew S. Alexander,
Molly Gasperini,
Peter T. Tsai,
Devin Gibbs,
Janelle M. Spinazzola,
Jamie L. Marshall,
Michael Feyder,
Mathew T. Pletcher,
Eugene L. Piatnitski Chekler,
Carl Morris,
Mustafa Şahin,
John F. Harms,
C J Schmidt,
Robin J. Kleiman,
Louis M. Kunkel
Publication year - 2016
Publication title -
translational psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.652
H-Index - 82
ISSN - 2158-3188
DOI - 10.1038/tp.2016.174
Subject(s) - dystrophin , phosphodiesterase , muscular dystrophy , wasting , medicine , neuroscience , duchenne muscular dystrophy , psychology , biology , enzyme , biochemistry
Duchenne muscular dystrophy is caused by mutations in the DYSTROPHIN gene. Although primarily associated with muscle wasting, a significant portion of patients (approximately 25%) are also diagnosed with autism spectrum disorder. We describe social behavioral deficits in dystrophin-deficient mice and present evidence of cerebellar deficits in cGMP production. We demonstrate therapeutic potential for selective inhibitors of the cGMP-specific PDE5A and PDE9A enzymes to restore social behaviors in dystrophin-deficient mice.
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