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Voltage‐gated Ca 2+  channels are key transducers of cellular excitability and participate in several crucial physiological responses. In vertebrates, 10 Ca 2+  channel genes, grouped in 3 families ( Ca   V   1, Ca   V   2  and  Ca   V   3 ), have been described and characterized. Insects possess only one member of each family. These genes have been isolated in a limited number of species and very few have been characterized although, in addition to their crucial role, they may represent a collateral target for neurotoxic insecticides. We have isolated the 3 genes coding for the 3 Ca 2+  channels expressed in  Apis mellifera . This work provides the first detailed characterization of the honeybee T-type Ca V 3 Ca 2+  channel and demonstrates the low toxicity of inhibiting this channel. Comparing Ca 2+  currents recorded in bee neurons and myocytes with Ca 2+  currents recorded in Xenopus oocytes expressing the honeybee  Ca   V   3  gene suggests native expression in bee muscle cells only. High‐voltage activated Ca 2+  channels could be recorded in the somata of different cultured bee neurons. These functional data were confirmed by  in situ  hybridization, immunolocalization and  in vivo  analysis of the effects of a Ca V 3 inhibitor. The biophysical and pharmacological characterization and the tissue distribution of Ca V 3 suggest a role in honeybee muscle function.

Honeybee locomotion is impaired by Am-CaV3 low voltage-activated Ca2+ channel antagonist