Multimodal Magnetic Resonance and Near-Infrared-Fluorescent Imaging of Intraperitoneal Ovarian Cancer Using a Dual-Mode-Dual-Gadolinium Liposomal Contrast Agent | Zendy

Murali Ravoori | Zendy; Sanjay K. Singh | Zendy; Rohan Bhavane | Zendy; Anil K. Sood | Zendy; Bahman Anvari | Zendy; James A. Bankson | Zendy; Ananth Annapragada | Zendy; Vikas Kundra | Zendy

Open Access

Multimodal Magnetic Resonance and Near-Infrared-Fluorescent Imaging of Intraperitoneal Ovarian Cancer Using a Dual-Mode-Dual-Gadolinium Liposomal Contrast Agent

Author(s) -

Murali Ravoori,

Sanjay K. Singh,

Rohan Bhavane,

Anil K. Sood,

Bahman Anvari,

James A. Bankson,

Ananth Annapragada,

Vikas Kundra

Publication year - 2016

Publication title -

scientific reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.24

H-Index - 213

ISSN - 2045-2322

DOI - 10.1038/srep38991

Subject(s) - magnetic resonance imaging , gadolinium , contrast (vision) , fluorescence , dual mode , liposome , ovarian cancer , dual (grammatical number) , nuclear magnetic resonance , imaging agent , medicine , pathology , chemistry , radiology , cancer , biology , physics , optics , biochemistry , in vivo , microbiology and biotechnology , organic chemistry , engineering , aerospace engineering , art , literature

The degree of tumor removal at surgery is a major factor in predicting outcome for ovarian cancer. A single multimodality agent that can be used with magnetic resonance (MR) for staging and pre-surgical planning, and with optical imaging to aid surgical removal of tumors, would present a new paradigm for ovarian cancer. We assessed whether a dual-mode, dual-Gadolinium (DM-Dual-Gd-ICG) contrast agent can be used to visualize ovarian tumors in the peritoneal cavity by multimodal MR and near infra-red imaging (NIR). Intraperitoneal ovarian tumors (Hey-A8 or OVCAR3) in mice enhanced on MR two days after intravenous DM-Dual Gd-ICG injection compared to controls (SNR, CNR, p < 0.05, n = 6). As seen on open abdomen and excised tumors views and confirmed by optical radiant efficiency measurement, Hey-A8 or OVCAR3 tumors from animals injected with DM-Dual Gd-ICG had increased fluorescence (p < 0.05, n = 6). This suggests clinical potential to localize ovarian tumors by MR for staging and surgical planning, and, by NIR at surgery for resection.

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