Nitrogen oxide cycle regulates nitric oxide levels and bacterial cell signaling | Zendy

Yasuyuki Sasaki | Zendy; Haruka Oguchi | Zendy; Takuya Kobayashi | Zendy; Shinichiro Kusama | Zendy; Ryo Sugiura | Zendy; Kenta Moriya | Zendy; Takuya Hirata | Zendy; Yuriya Yukioka | Zendy; Naoki Takaya | Zendy; Shunsuke Yajima | Zendy; Shinsaku Ito | Zendy; Kiyoshi Okada | Zendy; Kanju Ohsawa | Zendy; Haruo Ikeda | Zendy; Hideaki Takano | Zendy; Kenji Uéda | Zendy; Hirofumi Shoun | Zendy

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Nitrogen oxide cycle regulates nitric oxide levels and bacterial cell signaling

Author(s) -

Yasuyuki Sasaki,

Haruka Oguchi,

Takuya Kobayashi,

Shinichiro Kusama,

Ryo Sugiura,

Kenta Moriya,

Takuya Hirata,

Yuriya Yukioka,

Naoki Takaya,

Shunsuke Yajima,

Shinsaku Ito,

Kiyoshi Okada,

Kanju Ohsawa,

Haruo Ikeda,

Hideaki Takano,

Kenji Uéda,

Hirofumi Shoun

Publication year - 2016

Publication title -

scientific reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.24

H-Index - 213

ISSN - 2045-2322

DOI - 10.1038/srep22038

Subject(s) - nitric oxide , nitrite reductase , nitrate reductase , streptomyces coelicolor , microbiology and biotechnology , cell signaling , intracellular , nitrite , chemistry , cell cycle , signal transduction , bacteria , reactive nitrogen species , biology , biochemistry , enzyme , cell , nitrate , gene , genetics , organic chemistry , mutant

Nitric oxide (NO) signaling controls various metabolic pathways in bacteria and higher eukaryotes. Cellular enzymes synthesize and detoxify NO; however, a mechanism that controls its cellular homeostasis has not been identified. Here, we found a nitrogen oxide cycle involving nitrate reductase (Nar) and the NO dioxygenase flavohemoglobin (Fhb), that facilitate inter-conversion of nitrate, nitrite, and NO in the actinobacterium Streptomyces coelicolor . This cycle regulates cellular NO levels, bacterial antibiotic production, and morphological differentiation. NO down-regulates Nar and up-regulates Fhb gene expression via the NO-dependent transcriptional factors DevSR and NsrR, respectively, which are involved in the auto-regulation mechanism of intracellular NO levels. Nitrite generated by the NO cycles induces gene expression in neighboring cells, indicating an additional role of the cycle as a producer of a transmittable inter-cellular communication molecule.

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