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PcINF1 was previously found to induce pepper defense response by interacting with SRC2-1, but the underlying mechanism remains uninvestigated. Herein, we describe the involvement of SGT1 in the PcINF1/SRC2-1-induced immunity.  SGT1  was observed to be up-regulated by  Phytophthora capsici  inoculation and synergistically transient overexpression of  PcINF1 / SRC2-1  in pepper plants.  SGT1 -silencing compromised HR cell death, blocked H 2 O 2  accumulation, and downregulated HR-associated and hormones-dependent marker genes’ expression triggered by  PcINF1 / SRC2-1  co-overexpression. The interaction between SRC2-1 and SGT1 was found by the yeast two hybrid system and was further confirmed by bimolecular fluorescence complementation and co-immunoprecipitation analyses. The SGT1/SRC2-1 interaction was enhanced by transient overexpression of  PcINF1  and  Phytophthora capsici  inoculation, and  SGT1 -silencing attenuated PcINF1/SRC2-1 interaction. Additionally, by modulating subcellular localizations of SRC2-1, SGT1, and the interacting complex of SGT1/SRC2-1, it was revealed that exclusive nuclear targeting of the SGT1/SRC2-1 complex blocks immunity triggered by formation of SGT1/SRC2-1, and a translocation of the SGT1/SRC2-1 complex from the plasma membrane and cytoplasm to the nuclei upon the inoculation of  P. capsici . Our data demonstrate that the SGT1/SRC2-1 interaction, and its nucleocytoplasmic partitioning, is involved in pepper’s immunity against  P. capsici , thus providing a molecular link between Ca 2+  signaling associated SRC2-1 and SGT1-mediated defense signaling.

SGT1 is required in PcINF1/SRC2-1 induced pepper defense response by interacting with SRC2-1