Quantifying the cooperative subunit action in a multimeric membrane receptor | Zendy

Nisa Wongsamitkul | Zendy; Vasilica Nache | Zendy; Thomas Eick | Zendy; Sabine Hummert | Zendy; E. Schulz | Zendy; Ralf Schmauder | Zendy; Jana Schirmeyer | Zendy; Thomas Zimmer | Zendy; Klaus Benndorf | Zendy

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Quantifying the cooperative subunit action in a multimeric membrane receptor

Author(s) -

Nisa Wongsamitkul,

Vasilica Nache,

Thomas Eick,

Sabine Hummert,

E. Schulz,

Ralf Schmauder,

Jana Schirmeyer,

Thomas Zimmer,

Klaus Benndorf

Publication year - 2016

Publication title -

scientific reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.24

H-Index - 213

ISSN - 2045-2322

DOI - 10.1038/srep20974

Subject(s) - protein subunit , receptor , biophysics , microbiology and biotechnology , chemistry , ion channel , biochemistry , biology , gene

In multimeric membrane receptors the cooperative action of the subunits prevents exact knowledge about the operation and the interaction of the individual subunits. We propose a method that permits quantification of ligand binding to and activation effects of the individual binding sites in a multimeric membrane receptor. The power of this method is demonstrated by gaining detailed insight into the subunit action in olfactory cyclic nucleotide-gated CNGA2 ion channels.

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