Open AccessPSA reduction (after antibiotics) permits to avoid or postpone prostate biopsy in selected patients
Author(s) -
Vincenzo Serretta,
Anthony Catanese,
G Daricello,
Rosa Liotta,
Rosalinda Allegro,
Annamaria Martorana,
F Aragona,
D. Melloni
Publication year - 2007
Publication title -
prostate cancer and prostatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2
H-Index - 64
eISSN - 1476-5608
pISSN - 1365-7852
DOI - 10.1038/sj.pcan.4500996
Subject(s) - medicine , prostatitis , prostate cancer , urology , biopsy , prostate , prostate specific antigen , ciprofloxacin , antibiotics , cancer , histology , microbiology and biotechnology , biology
Microscopic foci of prostatitis may induce prostate-specific antigen (PSA) increase. PSA reduction after antibiotics might identify those patients in whom biopsy can be avoided. Ninety-nine patients received ciprofloxacin for 3 weeks, of whom 59 showed PSA reduction. Histology detected small foci of prostatitis in 65% of cases. Carcinoma was found in 40 and 20.3% of patients with unchanged or decreased PSA, respectively (P=0.03). No cancer was detected if PSA decreased below 4 ng/ml or more than 70%. Biopsy can be postponed, with a low risk of missing a cancer, if PSA decreases more than 70% or below 4 ng/ml.