Transient Focal Cerebral Ischemia Induces a Dramatic Activation of Small Ubiquitin-Like Modifier Conjugation | Zendy

Wei Yang | Zendy; Huaxin Sheng | Zendy; David S. Warner | Zendy; Wulf Paschen | Zendy

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Transient Focal Cerebral Ischemia Induces a Dramatic Activation of Small Ubiquitin-Like Modifier Conjugation

Author(s) -

Wei Yang,

Huaxin Sheng,

David S. Warner,

Wulf Paschen

Publication year - 2008

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/sj.jcbfm.9600601

Subject(s) - sumo protein , ischemia , ubiquitin , middle cerebral artery , microbiology and biotechnology , chemistry , transient (computer programming) , conjugate , neuroscience , biology , medicine , biochemistry , gene , computer science , operating system , mathematical analysis , mathematics

This study was designed to investigate whether small ubiquitin-like modifier (SUMO) conjugation is activated after focal cerebral ischemia. Transient ischemia induced a dramatic increase in SUMO2/3 protein conjugates. The most pronounced changes were found in the parietal cortex. SUMO2/3 conjugation was particularly high in neurons located at the border of the middle cerebral artery territory where sumoylated proteins translocated to the nucleus. Considering the marked effect of SUMO conjugation on the function of target proteins, it is very likely that the postischemic activation of sumoylation has a significant effect on the fate of neurons exposed to transient ischemia.

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