Spared Caudal Brainstem SERT Binding in Early Parkinson's Disease | Zendy

Roger L. Albin | Zendy; Robert A. Koeppe | Zendy; Nicolaas I. Bohnen | Zendy; K. Wernette | Zendy; Michael Kilbourn | Zendy; Kirk A. Frey | Zendy

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Spared Caudal Brainstem SERT Binding in Early Parkinson's Disease

Author(s) -

Roger L. Albin,

Robert A. Koeppe,

Nicolaas I. Bohnen,

K. Wernette,

Michael Kilbourn,

Kirk A. Frey

Publication year - 2007

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/sj.jcbfm.9600599

Subject(s) - brainstem , serotonin transporter , serotonergic , medicine , neuroscience , radioligand , endocrinology , psychology , serotonin , receptor

Postmortem data indicate loss of serotoninergic neurons in Parkinson's disease (PD). We used the serotonin transporter (SERT) radioligand 3-amino-4-(2-dimethylaminomethyl-phenylsulfaryl)-benzonitril (DASB) and positron emission tomography to examine SERT distribution and changes in early PD subjects. We studied five PD subjects (H&Y 1 to 2.5) and eight normal controls. There is reduced SERT binding in PD. The magnitude of DASB binding reductions was greater in the forebrain than in the brainstem regions. There was no asymmetry of diminished SERT binding. DASB binding in the medulla was relatively spared, inconsistent with the description of early prominent pathologic study in these caudal brainstem nuclei.

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