Open AccessIsotretinoin and fenofibrate induce adiposity with distinct effect on metabolic profile in a rat model of the insulin resistance syndrome
Author(s) -
Lucie Šedová,
Ondřej Šeda,
D Křenová,
Vladimı́r Křen,
Ludmila Kazdová
Publication year - 2004
Publication title -
international journal of obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.663
H-Index - 225
eISSN - 1476-5497
pISSN - 0307-0565
DOI - 10.1038/sj.ijo.0802613
Subject(s) - endocrinology , medicine , insulin resistance , fenofibrate , insulin , adipose tissue , metabolic syndrome , lipolysis , hyperinsulinemia , diabetes mellitus
To investigate the effect of transcription-modulating drugs, fenofibrate and isotretinoin, on metabolic profile, insulin sensitivity of adipose and muscle tissues and gene expression in a genetic model of insulin resistance syndrome, polydactylous rat strain (PD/Cub).