Open AccessLeptin increases circulating glucose, insulin and glucagon via sympathetic neural activation in fasted mice
Author(s) -
Bo Åhrén,
Peter J. Havel
Publication year - 1999
Publication title -
international journal of obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.663
H-Index - 225
eISSN - 1476-5497
pISSN - 0307-0565
DOI - 10.1038/sj.ijo.0800899
Subject(s) - medicine , endocrinology , leptin , glucagon , insulin , sympathetic nervous system , pancreatic hormone , insulin resistance , obesity , blood pressure
A number of recent studies suggest that leptin has effects on glucose metabolism and pancreatic hormone secretion. Therefore, the effect of leptin administration on circulating glucose, insulin and glucagon in fed and fasted mice was investigated. The potential contribution of the sympathetic nervous system to the effects of leptin was also examined.