Open AccessDegree of fatness after allogeneic BMT for childhood leukaemia or lymphoma
Author(s) -
Karsten Nysom,
Kirsten Holm,
Kim F. Michaelsen,
H Hertz,
N Jacobsen,
Jørn Müller,
Christian Mølgaard
Publication year - 2001
Publication title -
bone marrow transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 127
eISSN - 1476-5365
pISSN - 0268-3369
DOI - 10.1038/sj.bmt.1703012
Subject(s) - medicine , underweight , body mass index , percentile , total body irradiation , lymphoma , childhood leukaemia , acute lymphocytic leukemia , obesity , adipose tissue , lean body mass , pediatrics , leukemia , chemotherapy , body weight , overweight , cyclophosphamide , lymphoblastic leukemia , statistics , mathematics
Excess fatness is frequent after childhood ALL treated without BMT. We measured the whole-body percent fat by dual-energy X-ray absorptiometry and the body-mass index (weight/height(2) (kg/m(2)), BMI) in 25 survivors of childhood leukaemia or lymphoma (21 with ALL) who had received TBI and allogeneic BMT a median of 8 years ago (range 4-13). Adjusted for sex and age, the mean BMI was slightly but significantly reduced (0.4 s.d. below predicted) and the whole-body percent fat was significantly increased compared with healthy controls (1.1 s.d. above predicted). Eleven of 25 patients had a percent fat above the 90 percentile of the reference values, which indicates excess fatness. Adjusted for sex and age, a higher percent fat was related to additional cranial irradiation. Controlled for this, the whole-body percent fat seemed to be unrelated to age at BMT, length of follow-up, and previous chemotherapy. Compared with untransplanted ALL survivors treated with cranial irradiation, BMT survivors had significantly reduced BMI but similar whole body percent fat. BMI was a poor measure of body fatness in these patients. In conclusion, survivors of BMT for childhood leukaemia or lymphoma are adipose and slightly underweight and consequently have a substantially reduced lean body mass.