Open AccessSevere acute graft-versus-host disease occurring after syngeneic BMT for AML in a patient not given prior cyclosporin A therapy
Author(s) -
William Ying Khee Hwang,
Yeow Tee Goh,
C. L. Tan,
Gee Fung How,
HuiHui Tan
Publication year - 2000
Publication title -
bone marrow transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 127
eISSN - 1476-5365
pISSN - 0268-3369
DOI - 10.1038/sj.bmt.1702115
Subject(s) - medicine , conditioning regimen , graft versus host disease , immunology , transplantation , disease , stem cell , bone marrow , immune system , priming (agriculture) , hematopoietic stem cell transplantation , biology , genetics , germination , botany
A syndrome akin to graft-versus-host disease in the recipient of syngeneic stem cells is hitherto described as being milder, self-limiting and confined to the skin. It is enhanced by prior cyclosporin A therapy. We describe here a recipient of a syngeneic marrow transplant who did not receive priming with cyclosporin A and yet developed severe and progressive graft-versus-host disease which necessitated and responded to high-dose immunosuppressive therapy. We believe that this is because the conditioning regimen in stem cell transplant acts to reset the immune system enabling it to recognise 'self' antigens. Bone Marrow Transplantation (2000) 25, 205-207.