Severe acute graft-versus-host disease occurring after syngeneic BMT for AML in a patient not given prior cyclosporin A therapy | Zendy

William Ying Khee Hwang | Zendy; YT Goh | Zendy; C H Tan | Zendy; GF How | Zendy; HCP Tan | Zendy

Open Access

Severe acute graft-versus-host disease occurring after syngeneic BMT for AML in a patient not given prior cyclosporin A therapy

Author(s) -

William Ying Khee Hwang,

YT Goh,

C H Tan,

GF How,

HCP Tan

Publication year - 2000

Publication title -

bone marrow transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.609

H-Index - 127

eISSN - 1476-5365

pISSN - 0268-3369

DOI - 10.1038/sj.bmt.1702115

Subject(s) - medicine , conditioning regimen , graft versus host disease , immunology , transplantation , disease , stem cell , bone marrow , immune system , priming (agriculture) , hematopoietic stem cell transplantation , biology , genetics , germination , botany

A syndrome akin to graft-versus-host disease in the recipient of syngeneic stem cells is hitherto described as being milder, self-limiting and confined to the skin. It is enhanced by prior cyclosporin A therapy. We describe here a recipient of a syngeneic marrow transplant who did not receive priming with cyclosporin A and yet developed severe and progressive graft-versus-host disease which necessitated and responded to high-dose immunosuppressive therapy. We believe that this is because the conditioning regimen in stem cell transplant acts to reset the immune system enabling it to recognise 'self' antigens. Bone Marrow Transplantation (2000) 25, 205-207.

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