Atomic structure of the Y complex of the nuclear pore | Zendy

K. Kelley | Zendy; Kevin E. Knockenhauer | Zendy; Greg Kabachinski | Zendy; Thomas Schwartz | Zendy

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Atomic structure of the Y complex of the nuclear pore

Author(s) -

K. Kelley,

Kevin E. Knockenhauer,

Greg Kabachinski,

Thomas Schwartz

Publication year - 2015

Publication title -

nature structural and molecular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.448

H-Index - 270

eISSN - 1545-9993

pISSN - 1545-9985

DOI - 10.1038/nsmb.2998

Subject(s) - nuclear pore , core (optical fiber) , nucleus , protein structure , nuclear transport , gateway (web page) , biology , computational biology , chemistry , biophysics , crystallography , physics , microbiology and biotechnology , cell nucleus , computer science , biochemistry , world wide web , optics

The nuclear pore complex (NPC) is the principal gateway for transport into and out of the nucleus. Selectivity is achieved through the hydrogel-like core of the NPC. The structural integrity of the NPC depends on ~15 architectural proteins, which are organized in distinct subcomplexes to form the >40-MDa ring-like structure. Here we present the 4.1-Å crystal structure of a heterotetrameric core element ('hub') of the Y complex, the essential NPC building block, from Myceliophthora thermophila. Using the hub structure together with known Y-complex fragments, we built the entire ~0.5-MDa Y complex. Our data reveal that the conserved core of the Y complex has six rather than seven members. Evolutionarily distant Y-complex assemblies share a conserved core that is very similar in shape and dimension, thus suggesting that there are closely related architectural codes for constructing the NPC in all eukaryotes.

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