The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif | Zendy

Shengjiang Tu | Zendy; YuChing Teng | Zendy; Yuan Chun-hua | Zendy; YingTa Wu | Zendy; Meng-Yu Chan | Zendy; AnNing Cheng | Zendy; PoHsun Lin | Zendy; LiJung Juan | Zendy; MingDaw Tsai | Zendy

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The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif

Author(s) -

Shengjiang Tu,

YuChing Teng,

Yuan Chun-hua,

YingTa Wu,

Meng-Yu Chan,

AnNing Cheng,

PoHsun Lin,

LiJung Juan,

MingDaw Tsai

Publication year - 2008

Publication title -

nature structural and molecular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.448

H-Index - 270

eISSN - 1545-9993

pISSN - 1545-9985

DOI - 10.1038/nsmb.1400

Subject(s) - demethylase , histone , dna , chemistry , microbiology and biotechnology , hmg box , sequence motif , biochemistry , transcription factor , biology , dna binding protein , gene

The histone H3 lysine 4 demethylase RBP2 contains a DNA binding domain, the AT-rich interaction domain (ARID). We solved the structure of ARID by NMR, identified its DNA binding motif (CCGCCC) and characterized the binding contacts. Immunofluorescence and luciferase assays indicated that ARID is required for RBP2 demethylase activity in cells and that DNA recognition is essential to regulate transcription.

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