Open AccessFilovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus
Author(s) -
Ilhem Messaoudi,
Gaya K. Amarasinghe,
Christopher F. Basler
Publication year - 2015
Publication title -
nature reviews. microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 11.496
H-Index - 300
eISSN - 1740-1534
pISSN - 1740-1526
DOI - 10.1038/nrmicro3524
Subject(s) - ebola virus , virology , biology , viral pathogenesis , marburg virus , innate immune system , virus , viral replication , immune system , pathogenesis , filoviridae , immunology , immunity , ebolavirus , viral disease , paramyxoviridae
Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in West Africa. Filovirus disease is characterized by uncontrolled virus replication and the activation of host responses that contribute to pathogenesis. Underlying these phenomena is the potent suppression of host innate antiviral responses, particularly the type I interferon response, by viral proteins, which allows high levels of viral replication. In this Review, we describe the mechanisms used by filoviruses to block host innate immunity and discuss the links between immune evasion and filovirus pathogenesis.