Open AccessSingle proteins might have dual but related functions in intracellular and extracellular microenvironments
Author(s) -
Derek C. Radisky,
Melody Stallings-Mann,
Yohei Hirai,
Mina J. Bissell
Publication year - 2009
Publication title -
nature reviews. molecular cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 37.461
H-Index - 431
eISSN - 1471-0080
pISSN - 1471-0072
DOI - 10.1038/nrm2633
Subject(s) - microbiology and biotechnology , homeostasis , extracellular , intracellular , secretion , biology , function (biology) , chemistry , biochemistry
The maintenance of organ homeostasis and the control of an appropriate response to environmental alterations require the intimate coordination of cellular functions and tissue organization. An important component of this coordination could be provided by proteins that can have distinct but linked functions on both sides of the plasma membrane. We present a model that proposes that unconventional secretion provides a mechanism through which single proteins can integrate complex tissue functions.