Calcium signalling: dynamics, homeostasis and remodelling | Zendy

Michael J. Berridge | Zendy; Martin D. Bootman | Zendy; H. Llewelyn Roderick | Zendy

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Calcium signalling: dynamics, homeostasis and remodelling

Author(s) -

Michael J. Berridge,

Martin D. Bootman,

H. Llewelyn Roderick

Publication year - 2003

Publication title -

nature reviews molecular cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 37.461

H-Index - 431

eISSN - 1471-0080

pISSN - 1471-0072

DOI - 10.1038/nrm1155

Subject(s) - signalling , calcium signaling , intracellular , microbiology and biotechnology , homeostasis , dynamics (music) , biology , calcium , neuroscience , chemistry , physics , organic chemistry , acoustics

Ca2+ is a highly versatile intracellular signal that operates over a wide temporal range to regulate many different cellular processes. An extensive Ca2+-signalling toolkit is used to assemble signalling systems with very different spatial and temporal dynamics. Rapid highly localized Ca2+ spikes regulate fast responses, whereas slower responses are controlled by repetitive global Ca2+ transients or intracellular Ca2+ waves. Ca2+ has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease.

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