Dynamic stem cell states: naive to primed pluripotency in rodents and humans | Zendy

Leehee Weinberger | Zendy; Muneef Ayyash | Zendy; Noa Novershtern | Zendy; Jacob H. Hanna | Zendy

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Dynamic stem cell states: naive to primed pluripotency in rodents and humans

Author(s) -

Leehee Weinberger,

Muneef Ayyash,

Noa Novershtern,

Jacob H. Hanna

Publication year - 2016

Publication title -

nature reviews molecular cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 37.461

H-Index - 431

eISSN - 1471-0080

pISSN - 1471-0072

DOI - 10.1038/nrm.2015.28

Subject(s) - reprogramming , induced pluripotent stem cell , biology , somatic cell , cell potency , stem cell , microbiology and biotechnology , computational biology , neuroscience , embryonic stem cell , cell , genetics , gene

The molecular mechanisms and signalling pathways that regulate the in vitro preservation of distinct pluripotent stem cell configurations, and their induction in somatic cells by direct reprogramming, constitute a highly exciting area of research. In this Review, we integrate recent discoveries related to isolating unique naive and primed pluripotent stem cell states with altered functional and molecular characteristics, and from different species. We provide an overview of the pathways underlying pluripotent state transitions and interconversion in vitro and in vivo. We conclude by highlighting unresolved key questions, future directions and potential novel applications of such dynamic pluripotent cell states.

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