Of cancer and cave fish | Zendy

Robert A. Gatenby | Zendy; Robert J. Gillies | Zendy; Joel S. Brown | Zendy

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Of cancer and cave fish

Author(s) -

Robert A. Gatenby,

Robert J. Gillies,

Joel S. Brown

Publication year - 2011

Publication title -

nature reviews. cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.575

H-Index - 442

eISSN - 1474-1768

pISSN - 1474-175X

DOI - 10.1038/nrc3036

Subject(s) - context (archaeology) , cancer , fish <actinopterygii> , biology , carcinogenesis , cave , genetic architecture , computational biology , evolutionary biology , ecology , gene , genetics , fishery , phenotype , paleontology

We propose that the drivers of carcinogenesis lie more in the adaptive changes that are enabled by local or systemic alterations of tissue architecture than in the genetic changes observed in cancer cells. A full understanding of cancer biology and therapy through a cataloguing of the cancer genome is unlikely unless it is integrated into an evolutionary and ecological context.

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