High-Throughput Transcriptome Profiling Of Human Mesenchymal Stem Cells Reveals A Role For Wnt/GSK-3 Signaling In Their Hypoimmunomodulation | Zendy

Gurudutta Gangenahalli | Zendy; Neeraj Kumar Satija | Zendy; Farhat Afrin | Zendy; Rajender P. Tripathi | Zendy

Open Access

High-Throughput Transcriptome Profiling Of Human Mesenchymal Stem Cells Reveals A Role For Wnt/GSK-3 Signaling In Their Hypoimmunomodulation

Author(s) -

Gurudutta Gangenahalli,

Neeraj Kumar Satija,

Farhat Afrin,

Rajender P. Tripathi

Publication year - 2011

Publication title -

nature precedings

Language(s) - English

Resource type - Journals

ISSN - 1756-0357

DOI - 10.1038/npre.2011.5512.1

Subject(s) - mesenchymal stem cell , wnt signaling pathway , chemokine , microbiology and biotechnology , gsk 3 , immune system , transcriptome , biology , signal transduction , chemistry , cancer research , gene expression , immunology , gene , biochemistry

Mesenchymal stem cells (MSCs) are gaining importance among clinicians following recent demonstration of safe allogeneic transplantation due to their ability to modulate the immune response. However,the molecular machinery regulating the expression of immunomodulatory factors in MSCs is unknown. We, therefore, inhibited glycogen synthase kinase-3 (GSK-3),a Wnt signaling inhibitor, to elucidate the role of Wnt signaling in mediating immunoregulatory effects of human MSCs using gene expression profiling. Our results highlight enhanced ability of GSK-3 inhibitor (lithium) treated MSCs to evade immune response as a result of decreased expression of immune stimulatory cytokines and chemokines

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