Immunogenic Modulations Induced by Prospective Anti-Malarial Herbal Extracts in Murine Model | Zendy

Sudipta Chakraborty | Zendy; Swapna Chhetri | Zendy; Sajal Ray | Zendy; Shyamal Das Gupta | Zendy; S. Mukherjee | Zendy; Niladri Sekhar Bhunia | Zendy; Manoj Das | Zendy; Sanat K. Biswas | Zendy; Sreemayee Sarkar | Zendy; Guruprasad Mandal | Zendy; Dipankar Singha | Zendy; Chinmoy Karjee | Zendy

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Immunogenic Modulations Induced by Prospective Anti-Malarial Herbal Extracts in Murine Model

Author(s) -

Sudipta Chakraborty,

Swapna Chhetri,

Sajal Ray,

Shyamal Das Gupta,

S. Mukherjee,

Niladri Sekhar Bhunia,

Manoj Das,

Sanat K. Biswas,

Sreemayee Sarkar,

Guruprasad Mandal,

Dipankar Singha,

Chinmoy Karjee

Publication year - 2010

Publication title -

nature precedings

Language(s) - English

Resource type - Journals

ISSN - 1756-0357

DOI - 10.1038/npre.2010.4157.1

Subject(s) - traditional medicine , pharmacology , malaria , phytochemical , chemistry , medicine , biology , immunology

Keeping in view the ever increasing problem of drug resistance and affordability of the antimalarial drugs by the poor mass, herbal medicines can become an important and alternative sustainable strategy for malaria treatment. Aqueous extracts of three Himalayan herbs― _Equisetum ravense_, _Artemisia vulgaris_ and _Centella asiatica_, with reported antimalarial property were screened for clinical efficacy against a local strain of _Plasmodium vivax_ antigen in murine model. _E. arvense_ extract was consistent in boosting phagocytic activity, nitric oxide generation, acid phosphatase and alkaline phosphatase activities in the peritoneal macrophages. The effectiveness of the rest herbals was discrete. A need for further detailed investigation to evaluate the clinical efficacy of these herbals seems essential.

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