Extragenic Suppression analysis of TS mutations using Sec61p | Zendy

Sterling Smith | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Extragenic Suppression analysis of TS mutations using Sec61p

Author(s) -

Sterling Smith

Publication year - 2007

Publication title -

nature precedings

Language(s) - English

Resource type - Journals

ISSN - 1756-0357

DOI - 10.1038/npre.2007.651.1

Subject(s) - endoplasmic reticulum , chaperone (clinical) , membrane protein , protein folding , secretory protein , chemistry , secretory pathway , microbiology and biotechnology , translocon , biophysics , membrane , biochemistry , biology , secretion , medicine , pathology , golgi apparatus

During synthesis, secretory and membrane proteins are cotranslationally translocated into the lumen of the endoplasmic reticulum through an aqueous gated channel. Proper folding, degradation, and transport of many polypeptides depend on a diverse set of helper proteins termed chaperone. I hypothesize that Sec 61p is a membrane chaperone, which actively directs membrane protein folding.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research