Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit? | Zendy

Eric Burguière | Zendy; Angelo Arleo | Zendy; Mohammad Reza Hojjati | Zendy; Ype Elgersma | Zendy; Chris I. De Zeeuw | Zendy; Alain Berthoz | Zendy; Laure RondiReig | Zendy

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Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?

Author(s) -

Eric Burguière,

Angelo Arleo,

Mohammad Reza Hojjati,

Ype Elgersma,

Chris I. De Zeeuw,

Alain Berthoz,

Laure RondiReig

Publication year - 2005

Publication title -

nature neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 13.403

H-Index - 422

eISSN - 1546-1726

pISSN - 1097-6256

DOI - 10.1038/nn1532

Subject(s) - neuroscience , psychology , adaptation (eye) , motor learning , cognitive psychology , spatial learning , procedural memory , task (project management) , cognition , management , economics

L7-PKCI transgenic mice, which lack parallel fiber-Purkinje cell long-term depression (LTD), were tested with two different mazes to dissociate the relative importance of declarative and procedural components of spatial navigation. We show that L7-PKCI mice are deficient in acquisition of an adapted goal-oriented behavior, part of the procedural component of the task. This supports the hypothesis that cerebellar LTD may subserve a general sensorimotor adaptation process shared by motor and spatial learning functions.

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