Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula | Zendy

Frank J. Meye | Zendy; Kristina Valentinova | Zendy; Salvatore Lecca | Zendy; Lucile MarionPoll | Zendy; Matthieu Maroteaux | Zendy; Stefano Musardo | Zendy; Imane Moutkine | Zendy; Fabrizio Gardoni | Zendy; Richard L. Huganir | Zendy; François Georges | Zendy; Manuel Mameli | Zendy

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Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula

Author(s) -

Frank J. Meye,

Kristina Valentinova,

Salvatore Lecca,

Lucile MarionPoll,

Matthieu Maroteaux,

Stefano Musardo,

Imane Moutkine,

Fabrizio Gardoni,

Richard L. Huganir,

François Georges,

Manuel Mameli

Publication year - 2015

Publication title -

nature neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 13.403

H-Index - 422

eISSN - 1546-1726

pISSN - 1097-6256

DOI - 10.1038/nn.3923

Subject(s) - glutamatergic , habenula , ampa receptor , neuroscience , ventral tegmental area , addiction , neurotransmission , psychology , biology , glutamate receptor , central nervous system , receptor , dopamine , dopaminergic , biochemistry

Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K(+) currents and increased excitability. GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications and drug-driven aversive behaviors. Altogether, our results suggest that long-lasting adaptations in LHb shape negative symptoms after drug taking.

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