Open AccessReal-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli
Author(s) -
Mitchell F. Roitman,
Robert Wheeler,
R. Mark Wightman,
Regina M. Carelli
Publication year - 2008
Publication title -
nature neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 13.403
H-Index - 422
eISSN - 1546-1726
pISSN - 1097-6256
DOI - 10.1038/nn.2219
Subject(s) - nucleus accumbens , neuroscience , aversive stimulus , dopamine , psychology , reward system
Rewarding and aversive stimuli evoke very different patterns of behavior and are rapidly discriminated. Here taste stimuli of opposite hedonic valence evoked opposite patterns of dopamine and metabolic activity within milliseconds in the nucleus accumbens. This rapid encoding may serve to guide ongoing behavioral responses and promote plastic changes in underlying circuitry.
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