Impact of outdated gene annotations on pathway enrichment analysis | Zendy

Lina Wadi | Zendy; Mona Meyer | Zendy; Joel Weiser | Zendy; Lincoln Stein | Zendy; Jüri Reimand | Zendy

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Impact of outdated gene annotations on pathway enrichment analysis

Author(s) -

Lina Wadi,

Mona Meyer,

Joel Weiser,

Lincoln Stein,

Jüri Reimand

Publication year - 2016

Publication title -

nature methods

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.469

H-Index - 318

eISSN - 1548-7105

pISSN - 1548-7091

DOI - 10.1038/nmeth.3963

Subject(s) - annotation , gene , gene annotation , computational biology , pathway analysis , genome , biology , vocabulary , genetics , bioinformatics , gene expression , linguistics , philosophy

To the Editor: Pathway enrichment analysis is a common technique for interpreting gene lists derived from high-throughput experiments1. Its success depends on the quality of gene annotations. We analyzed the evolution of pathway knowledge and annotations over the past seven years and found that the use of outdated resources has strongly… Download references

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