Improved and expanded Q-system reagents for genetic manipulations | Zendy

Olena Riabinina | Zendy; David J. Luginbuhl | Zendy; Elizabeth E. Marr | Zendy; Sha Liu | Zendy; Mark N. Wu | Zendy; Liqun Luo | Zendy; Christopher J. Potter | Zendy

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Improved and expanded Q-system reagents for genetic manipulations

Author(s) -

Olena Riabinina,

David J. Luginbuhl,

Elizabeth E. Marr,

Sha Liu,

Mark N. Wu,

Liqun Luo,

Christopher J. Potter

Publication year - 2015

Publication title -

nature methods

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.469

H-Index - 318

eISSN - 1548-7105

pISSN - 1548-7091

DOI - 10.1038/nmeth.3250

Subject(s) - drosophila melanogaster , transgene , biology , computational biology , activator (genetics) , model system , microbiology and biotechnology , genetics , gene

The Q system is a repressible binary expression system for transgenic manipulations in living organisms. Through protein engineering and in vivo functional tests, we report here variants of the Q-system transcriptional activator, including QF2, for driving strong and ubiquitous expression in all Drosophila tissues. Our QF2, Gal4QF and LexAQF chimeric transcriptional activators substantially enrich the toolkit available for transgenic regulation in Drosophila melanogaster.

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