Chip–NMR biosensor for detection and molecular analysis of cells | Zendy

Hakho Lee | Zendy; Eric Sun | Zendy; Donhee Ham | Zendy; Ralph Weissleder | Zendy

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Chip–NMR biosensor for detection and molecular analysis of cells

Author(s) -

Hakho Lee,

Eric Sun,

Donhee Ham,

Ralph Weissleder

Publication year - 2008

Publication title -

nature medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.536

H-Index - 547

eISSN - 1546-170X

pISSN - 1078-8956

DOI - 10.1038/nm.1711

Subject(s) - biosensor , sensitivity (control systems) , nanotechnology , materials science , computer science , biomedical engineering , electronic engineering , medicine , engineering

Rapid and accurate measurement of biomarkers in tissue and fluid samples is a major challenge in medicine. Here we report the development of a new, miniaturized diagnostic magnetic resonance (DMR) system for multiplexed, quantitative and rapid analysis. By using magnetic particles as a proximity sensor to amplify molecular interactions, the handheld DMR system can perform measurements on unprocessed biological samples. We show the capability of the DMR system by using it to detect bacteria with high sensitivity, identify small numbers of cells and analyze them on a molecular level in real time, and measure a series of protein biomarkers in parallel. The DMR technology shows promise as a robust and portable diagnostic device.

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