An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells | Zendy

Gérard Eberl | Zendy; Shana Marmon | Zendy; Mary Jean Sunshine | Zendy; Paul D. Rennert | Zendy; Yongwon Choi | Zendy; Dan R. Littman | Zendy

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An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells

Author(s) -

Gérard Eberl,

Shana Marmon,

Mary Jean Sunshine,

Paul D. Rennert,

Yongwon Choi,

Dan R. Littman

Publication year - 2003

Publication title -

nature immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.074

H-Index - 388

eISSN - 1529-2916

pISSN - 1529-2908

DOI - 10.1038/ni1022

Subject(s) - lymphotoxin , lymph node , lymphatic system , biology , lymphotoxin beta receptor , microbiology and biotechnology , inducer , immunology , lymph , cytokine , pathology , medicine , biochemistry , gene

Lymphoid tissue inducer (LTi) cells are associated with early development of lymph nodes and Peyer's patches. We show here that during fetal life the nuclear hormone receptor RORgamma(t) is expressed exclusively in and is required for the generation of LTi cells. RORgamma(t+) LTi cells provide essential factors, among which lymphotoxin-alpha1beta2 is necessary but not sufficient for activation of the mesenchyma in lymph node and Peyer's patch anlagen. This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues.

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