Mapping the strand-specific transcriptome of fission yeast | Zendy

T Gingeras | Zendy

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Mapping the strand-specific transcriptome of fission yeast

Author(s) -

T Gingeras

Publication year - 2008

Publication title -

nature genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 18.861

H-Index - 573

eISSN - 1546-1718

pISSN - 1061-4036

DOI - 10.1038/ng0808-935

Subject(s) - biology , transcriptome , yeast , fission , computational biology , schizosaccharomyces , genetics , microbiology and biotechnology , saccharomyces cerevisiae , schizosaccharomyces pombe , gene , gene expression , physics , quantum mechanics , neutron

Pervasive genome-wide transcription is widespread in eukaryotic cells, but key features of the transcriptome have yet to be fully characterized. A new study using antibody-based detection of RNA-DNA duplexes on tiling arrays now reveals a complex, strand-specific transcriptional world in fission yeast. The biochemical evidence for pervasive genome-wide transcription has been well established for many organisms1, 2. These and many other studies point to a transcriptional organization for many genomes that can be characterized as highly interleaved (Fig. 1

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