A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer | Zendy

Ali Amin Al Olama | Zendy; Zsofia KoteJarai | Zendy; Sonja I. Berndt | Zendy; David V. Conti | Zendy; Fredrick R. Schumacher | Zendy; Ying Han | Zendy; Sara Benlloch | Zendy; Dennis J. Hazelett | Zendy; Zhaoming Wang | Zendy; Edward J. Saunders | Zendy; Daniel Leongamornlert | Zendy; Sara Lindström | Zendy; Sara Jugurnauth-Little | Zendy; Tokhir Dadaev | Zendy; Malgorzata Tymrakiewicz | Zendy; Daniel O. Stram | Zendy; Kristin A. Rand | Zendy; Peggy Wan | Zendy; Alex Stram | Zendy; Xin Sheng | Zendy; Loreall Pooler | Zendy; Karen Park | Zendy; Lucy Xia | Zendy; Jonathan P. Tyrer | Zendy; Laurence N. Kolonel | Zendy; Loı̈c Le Marchand | Zendy; Robert N. Hoover | Zendy; Mitchell J. Machiela | Zendy; Merideth Yeager | Zendy; Laurie Burdette | Zendy; Charles C. Chung | Zendy; Amy Hutchinson | Zendy; Kai Yu | Zendy; Chee Goh | Zendy; Mahbubl Ahmed | Zendy; Koveela Govindasami | Zendy; Michelle Guy | Zendy; Teuvo L.J. Tammela | Zendy; Anssi Auvinen | Zendy; Tiina Wahlfors | Zendy; Johanna Schleutker | Zendy; Tapio Visakorpi | Zendy; Katri A. Lein | Zendy; Jianfeng Xu | Zendy; Markus Aly | Zendy; Jenny Donovan | Zendy; Ruth C. Travis | Zendy; Timothy J. Key | Zendy; Afshan Siddiq | Zendy; Federico Canzian | Zendy; KayTee Khaw | Zendy; Atsushi Takahashi | Zendy; Michiaki Kubo | Zendy; Paul D.P. Pharoah | Zendy; Nora Pashayan | Zendy; Maren Weischer | Zendy; Børge G. Nordestgaard | Zendy; Sune F. Nielsen | Zendy; Peter Klarskov | Zendy; Martin Andreas Røder | Zendy; Peter Iversen | Zendy; Stephen N. Thibodeau | Zendy; Shan K. McDonnell | Zendy; Daniel J. Schaid | Zendy; Janet L. Stanford | Zendy; Suzanne Kolb | Zendy; Sarah K. Holt | Zendy; Beatrice Knudsen | Zendy; Antonio Hurtado Coll | Zendy; Susan M. Gapstur | Zendy; W. Ryan Diver | Zendy; Victoria L. Stevens | Zendy; Christiane Maier | Zendy; Manuel Luedeke | Zendy; Kathleen Herkommer | Zendy; Antje E. Rinckleb | Zendy; Sara S. Strom | Zendy; Curtis A. Pettaway | Zendy; Edward D. Yeboah | Zendy; Yao Tettey | Zendy; Richard Biritwum | Zendy; Andrew A. Adjei | Zendy; Evelyn Tay | Zendy; Ann Truelove | Zendy; Shelley Niwa | Zendy; Anand P. Chokkalingam | Zendy; Lisa CanAlbright | Zendy; Cezary Cybulski | Zendy; Dominika Wokołorczyk | Zendy; Wojciech Kluźniak | Zendy; Jong Moon Park | Zendy; Thomas A. Sellers | Zendy; HuiYi Lin | Zendy; William B. Isaacs | Zendy; Alan W. Partin | Zendy; Hermann Brenner | Zendy; Aida Karina Dieffenbach | Zendy; Christa Stegmaier | Zendy; Constance Chen | Zendy; Edward L. Giovannucci | Zendy; Jing Ma | Zendy; Meir J. Stampfer | Zendy; Kathryn L. Penney | Zendy; Lorelei A. Mucci | Zendy; Esther M. John | Zendy; Sue A. Ingles | Zendy; Rick A. Kittles | Zendy; Adam B. Murphy | Zendy; Hardev Pandha | Zendy; Agnieszka Michael | Zendy; Andrzej Kierzek | Zendy; William J. Blot | Zendy; Lisa B. Signorello | Zendy; Wei Zheng | Zendy; Demetrius Albanes | Zendy; Jarmo Virtamo | Zendy; Stephanie J. Weinstein | Zendy; Barbara Nemesure | Zendy; John D. Carpten | Zendy; Cristina Leske | Zendy; Suh-Yuh Wu | Zendy; Anselm Hennis | Zendy; Adam S. Kibel | Zendy; Benjamin A. Rybicki | Zendy; Christine NeslundDudas | Zendy; Ann W. Hsing | Zendy; Lisa W. Chu | Zendy; Phyllis J. Goodman | Zendy; Eric A. Klein | Zendy; S. Lilly Zheng | Zendy; Jyotsna Batra | Zendy; Judith A. Clements | Zendy; Amanda B. Spurdle | Zendy; Manuel R. Teixeira | Zendy; Paula Paulo | Zendy; Sofia Maia | Zendy; Chavdar Slavov | Zendy; Radka Kaneva | Zendy; Vanio Mitev | Zendy; John S. Witte | Zendy; Graham Casey | Zendy; Elizabeth M. Gillanders | Zendy; Daniella Seminara | Zendy; Elio Ríboli | Zendy; Freddie C. Hamdy | Zendy; Gerhard A. Coetzee | Zendy; Qiyuan Li | Zendy; Matthew L. Freedman | Zendy; David J. Hunter | Zendy; Kenneth Muir | Zendy; Henrik Grönberg | Zendy; David E. Neal | Zendy; Melissa C. Southey | Zendy; Graham G. Giles | Zendy; Gianluca Severi | Zendy; Michael B. Cook | Zendy; Hidewaki Nakagawa | Zendy; Fredrik Wiklund | Zendy; Peter Kraft | Zendy; Stephen J. Chanock | Zendy; Brian E. Henderson | Zendy; Douglas F. Easton | Zendy; Rosalind A. Eeles | Zendy; Christopher A. Haiman | Zendy

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A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

Author(s) -

Ali Amin Al Olama,

Zsofia KoteJarai,

Sonja I. Berndt,

David V. Conti,

Fredrick R. Schumacher,

Ying Han,

Sara Benlloch,

Dennis J. Hazelett,

Zhaoming Wang,

Edward J. Saunders,

Daniel Leongamornlert,

Sara Lindström,

Sara Jugurnauth-Little,

Tokhir Dadaev,

Malgorzata Tymrakiewicz,

Daniel O. Stram,

Kristin A. Rand,

Peggy Wan,

Alex Stram,

Xin Sheng,

Loreall Pooler,

Karen Park,

Lucy Xia,

Jonathan P. Tyrer,

Laurence N. Kolonel,

Loı̈c Le Marchand,

Robert N. Hoover,

Mitchell J. Machiela,

Merideth Yeager,

Laurie Burdette,

Charles C. Chung,

Amy Hutchinson,

Kai Yu,

Chee Goh,

Mahbubl Ahmed,

Koveela Govindasami,

Michelle Guy,

Teuvo L.J. Tammela,

Anssi Auvinen,

Tiina Wahlfors,

Johanna Schleutker,

Tapio Visakorpi,

Katri A. Lein,

Jianfeng Xu,

Markus Aly,

Jenny Donovan,

Ruth C. Travis,

Timothy J. Key,

Afshan Siddiq,

Federico Canzian,

KayTee Khaw,

Atsushi Takahashi,

Michiaki Kubo,

Paul D.P. Pharoah,

Nora Pashayan,

Maren Weischer,

Børge G. Nordestgaard,

Sune F. Nielsen,

Peter Klarskov,

Martin Andreas Røder,

Peter Iversen,

Stephen N. Thibodeau,

Shan K. McDonnell,

Daniel J. Schaid,

Janet L. Stanford,

Suzanne Kolb,

Sarah K. Holt,

Beatrice Knudsen,

Antonio Hurtado Coll,

Susan M. Gapstur,

W. Ryan Diver,

Victoria L. Stevens,

Christiane Maier,

Manuel Luedeke,

Kathleen Herkommer,

Antje E. Rinckleb,

Sara S. Strom,

Curtis A. Pettaway,

Edward D. Yeboah,

Yao Tettey,

Richard Biritwum,

Andrew A. Adjei,

Evelyn Tay,

Ann Truelove,

Shelley Niwa,

Anand P. Chokkalingam,

Lisa CanAlbright,

Cezary Cybulski,

Dominika Wokołorczyk,

Wojciech Kluźniak,

Jong Moon Park,

Thomas A. Sellers,

HuiYi Lin,

William B. Isaacs,

Alan W. Partin,

Hermann Brenner,

Aida Karina Dieffenbach,

Christa Stegmaier,

Constance Chen,

Edward L. Giovannucci,

Jing Ma,

Meir J. Stampfer,

Kathryn L. Penney,

Lorelei A. Mucci,

Esther M. John,

Sue A. Ingles,

Rick A. Kittles,

Adam B. Murphy,

Hardev Pandha,

Agnieszka Michael,

Andrzej Kierzek,

William J. Blot,

Lisa B. Signorello,

Wei Zheng,

Demetrius Albanes,

Jarmo Virtamo,

Stephanie J. Weinstein,

Barbara Nemesure,

John D. Carpten,

Cristina Leske,

Suh-Yuh Wu,

Anselm Hennis,

Adam S. Kibel,

Benjamin A. Rybicki,

Christine NeslundDudas,

Ann W. Hsing,

Lisa W. Chu,

Phyllis J. Goodman,

Eric A. Klein,

S. Lilly Zheng,

Jyotsna Batra,

Judith A. Clements,

Amanda B. Spurdle,

Manuel R. Teixeira,

Paula Paulo,

Sofia Maia,

Chavdar Slavov,

Radka Kaneva,

Vanio Mitev,

John S. Witte,

Graham Casey,

Elizabeth M. Gillanders,

Daniella Seminara,

Elio Ríboli,

Freddie C. Hamdy,

Gerhard A. Coetzee,

Qiyuan Li,

Matthew L. Freedman,

David J. Hunter,

Kenneth Muir,

Henrik Grönberg,

David E. Neal,

Melissa C. Southey,

Graham G. Giles,

Gianluca Severi,

Michael B. Cook,

Hidewaki Nakagawa,

Fredrik Wiklund,

Peter Kraft,

Stephen J. Chanock,

Brian E. Henderson,

Douglas F. Easton,

Rosalind A. Eeles,

Christopher A. Haiman

Publication year - 2014

Publication title -

nature genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 18.861

H-Index - 573

eISSN - 1546-1718

pISSN - 1061-4036

DOI - 10.1038/ng.3094

Subject(s) - prostate cancer , genome wide association study , biology , single nucleotide polymorphism , disease , cancer , genetics , genetic association , meta analysis , oncology , genotype , medicine , gene

Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of > 10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.

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