A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia | Zendy

Helen E. Speedy | Zendy; Maria Chiara Di Bernardo | Zendy; Georgina P. Sava | Zendy; Martin J.S. Dyer | Zendy; Amy Holroyd | Zendy; Yufei Wang | Zendy; Nicola J. Sunter | Zendy; Larry Mansouri | Zendy; Gunnar Juliusson | Zendy; Karin E. Smedby | Zendy; Göran Roos | Zendy; Sandrine Jayne | Zendy; Aneela Majid | Zendy; Claire Dearden | Zendy; Emma A. Hall | Zendy; Tryfonia MainouFowler | Zendy; Graham Jackson | Zendy; Geoffrey Summerfield | Zendy; Robert J. Harris | Zendy; Andrew R. Pettitt | Zendy; David Allsup | Zendy; James R Bailey | Zendy; Guy Pratt | Zendy; Chris Pepper | Zendy; Chris Fegan | Zendy; Richard Rosenquist | Zendy; Daniel Catovsky | Zendy; James M. Allan | Zendy; Richard S. Houlston | Zendy

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A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia

Author(s) -

Helen E. Speedy,

Maria Chiara Di Bernardo,

Georgina P. Sava,

Martin J.S. Dyer,

Amy Holroyd,

Yufei Wang,

Nicola J. Sunter,

Larry Mansouri,

Gunnar Juliusson,

Karin E. Smedby,

Göran Roos,

Sandrine Jayne,

Aneela Majid,

Claire Dearden,

Emma A. Hall,

Tryfonia MainouFowler,

Graham Jackson,

Geoffrey Summerfield,

Robert J. Harris,

Andrew R. Pettitt,

David Allsup,

James R Bailey,

Guy Pratt,

Chris Pepper,

Chris Fegan,

Richard Rosenquist,

Daniel Catovsky,

James M. Allan,

Richard S. Houlston

Publication year - 2013

Publication title -

nature genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 18.861

H-Index - 573

eISSN - 1546-1718

pISSN - 1061-4036

DOI - 10.1038/ng.2843

Subject(s) - genome wide association study , chronic lymphocytic leukemia , biology , genetic association , genetics , single nucleotide polymorphism , genetic predisposition , leukemia , genotype , gene

Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 × 10(-9)), 4q26 (rs6858698, P = 3.07 × 10(-9)), 6q25.2 (IPCEF1, rs2236256, P = 1.50 × 10(-10)) and 7q31.33 (POT1, rs17246404, P = 3.40 × 10(-8)). Additionally, we identified a promising association at 5p15.33 (CLPTM1L, rs31490, P = 1.72 × 10(-7)) and validated recently reported putative associations at 5p15.33 (TERT, rs10069690, P = 1.12 × 10(-10)) and 8q22.3 (rs2511714, P = 2.90 × 10(-9)). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CLL.

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