Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome | Zendy

Christopher J. Lessard | Zendy; He Li | Zendy; Indra Adrianto | Zendy; John A. Ice | Zendy; Astrid Rasmussen | Zendy; Kiely Grundahl | Zendy; Jennifer A. Kelly | Zendy; Mikhail G. Dozmorov | Zendy; Corinne MiceliRichard | Zendy; Simon Bowman | Zendy; Sue Lester | Zendy; Per Eriksson | Zendy; MaijaLeena Eloranta | Zendy; Johan G. Brun | Zendy; Lasse G. Gøransson | Zendy; Erna Harboe | Zendy; Joel M. Guthridge | Zendy; Kenneth M. Kaufman | Zendy; Marika Kvarnström | Zendy; Helmi Jazebi | Zendy; Deborah S. Cunninghame Graham | Zendy; Martha Grandits | Zendy; Abu N M Nazmul-Hossain | Zendy; Ketan Patel | Zendy; Adam J. Adler | Zendy; Jacen S. MaierMoore | Zendy; A. Darise Farris | Zendy; Michael T. Brennan | Zendy; James Lessard | Zendy; James Chodosh | Zendy; Rajaram Gopalakrishnan | Zendy; Kimberly S Hefner | Zendy; J. Graeme Houston | Zendy; Andrew Huang | Zendy; Pamela Hughes | Zendy; David M. Lewis | Zendy; Lida Radfar | Zendy; Michael D. Rohrer | Zendy; Donald U. Stone | Zendy; Jonathan D. Wren | Zendy; Timothy J. Vyse | Zendy; Patrick M. Gaffney | Zendy; Judith A. James | Zendy; Roald Omdal | Zendy; Marie WahrenHerlenius | Zendy; Gabor G Illei | Zendy; Torsten Witte | Zendy; Roland Jonsson | Zendy; Maureen Rischmueller | Zendy; Lars Rönnblom | Zendy; Gunnel Nordmark | Zendy; WanFai Ng | Zendy; Xavier Mariette | Zendy; JuanManuel Anaya | Zendy; Nelson L. Rhodus | Zendy; Barbara M Segal | Zendy; R. Hal Scofield | Zendy; Courtney G. Montgomery | Zendy; John B. Harley | Zendy; Kathy L Sivils | Zendy

Open Access

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

Author(s) -

Christopher J. Lessard,

He Li,

Indra Adrianto,

John A. Ice,

Astrid Rasmussen,

Kiely Grundahl,

Jennifer A. Kelly,

Mikhail G. Dozmorov,

Corinne MiceliRichard,

Simon Bowman,

Sue Lester,

Per Eriksson,

MaijaLeena Eloranta,

Johan G. Brun,

Lasse G. Gøransson,

Erna Harboe,

Joel M. Guthridge,

Kenneth M. Kaufman,

Marika Kvarnström,

Helmi Jazebi,

Deborah S. Cunninghame Graham,

Martha Grandits,

Abu N M Nazmul-Hossain,

Ketan Patel,

Adam J. Adler,

Jacen S. MaierMoore,

A. Darise Farris,

Michael T. Brennan,

James Lessard,

James Chodosh,

Rajaram Gopalakrishnan,

Kimberly S Hefner,

J. Graeme Houston,

Andrew Huang,

Pamela Hughes,

David M. Lewis,

Lida Radfar,

Michael D. Rohrer,

Donald U. Stone,

Jonathan D. Wren,

Timothy J. Vyse,

Patrick M. Gaffney,

Judith A. James,

Roald Omdal,

Marie WahrenHerlenius,

Gabor G Illei,

Torsten Witte,

Roland Jonsson,

Maureen Rischmueller,

Lars Rönnblom,

Gunnel Nordmark,

WanFai Ng,

Xavier Mariette,

JuanManuel Anaya,

Nelson L. Rhodus,

Barbara M Segal,

R. Hal Scofield,

Courtney G. Montgomery,

John B. Harley,

Kathy L Sivils

Publication year - 2013

Publication title -

nature genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 18.861

H-Index - 573

eISSN - 1546-1718

pISSN - 1061-4036

DOI - 10.1038/ng.2792

Subject(s) - immunology , biology , acquired immune system , innate immune system , immune system , autoimmunity

Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report results of a large-scale association study of Sjögren's syndrome. In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (Pmeta = 7.65 × 10(-114)), we establish associations with IRF5-TNPO3 (Pmeta = 2.73 × 10(-19)), STAT4 (Pmeta = 6.80 × 10(-15)), IL12A (Pmeta = 1.17 × 10(-10)), FAM167A-BLK (Pmeta = 4.97 × 10(-10)), DDX6-CXCR5 (Pmeta = 1.10 × 10(-8)) and TNIP1 (Pmeta = 3.30 × 10(-8)). We also observed suggestive associations (Pmeta < 5 × 10(-5)) with variants in 29 other regions, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others. These results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome.

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