Open AccessTwo new susceptibility loci for Kawasaki disease identified through genome-wide association analysis
Author(s) -
YiChing Lee,
HoChang Kuo,
Jeng-Sheng Chang,
LuanYin Chang,
LiMin Huang,
MingRen Chen,
ChiDi Liang,
Hsin Chi,
Chao Huang,
Meng-Luen Lee,
Daniel TsungNing Huang,
Betau Hwang,
NanChang Chiu,
KaoPin Hwang,
Pi-Chang Lee,
Li-Ching Chang,
Yimin Liu,
YingJu Chen,
Chien-Hsiun Chen,
Yuan-Tsong Chen,
FuuJen Tsai,
J.-Y. Wu
Publication year - 2012
Publication title -
nature genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 18.861
H-Index - 573
eISSN - 1546-1718
pISSN - 1061-4036
DOI - 10.1038/ng.2227
Subject(s) - kawasaki disease , genome wide association study , biology , vasculitis , disease , immunology , genetic association , genetics , immune system , gene , single nucleotide polymorphism , genotype , medicine , artery
To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10(-8)). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis.
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