Open AccessTarget class drug discovery
Author(s) -
Kimberly D. Barnash,
Lindsey I. James,
Stephen V. Frye
Publication year - 2017
Publication title -
nature chemical biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.412
H-Index - 216
eISSN - 1552-4469
pISSN - 1552-4450
DOI - 10.1038/nchembio.2473
Subject(s) - drug discovery , computational biology , selection (genetic algorithm) , class (philosophy) , focus (optics) , biology , data science , drug class , drug , computer science , bioinformatics , pharmacology , artificial intelligence , physics , optics
Selection of molecular targets based on disease understanding is a dominant paradigm in drug discovery. We argue that a focus on classes of targets with central roles in biology provides a complementary approach that has higher quality outcomes in early discovery efforts.
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