Integrin αvβ3 Expression in Colon Carcinoma Correlates with Survival | Zendy

Alain Vonlaufen | Zendy; Guido Wiedle | Zendy; Bettina Borisch | Zendy; Stefan Birrer | Zendy; Peter Luder | Zendy; Beat A. Imhof | Zendy

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Integrin αvβ3 Expression in Colon Carcinoma Correlates with Survival

Author(s) -

Alain Vonlaufen,

Guido Wiedle,

Bettina Borisch,

Stefan Birrer,

Peter Luder,

Beat A. Imhof

Publication year - 2001

Publication title -

modern pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.596

H-Index - 153

eISSN - 1530-0285

pISSN - 0893-3952

DOI - 10.1038/modpathol.3880447

Subject(s) - integrin , alpha (finance) , pathology , angiogenesis , beta (programming language) , immunohistochemistry , medicine , colorectal cancer , alpha v beta 3 , carcinoma , neovascularization , blood vessel , monoclonal antibody , cancer research , antibody , cancer , immunology , receptor , vitronectin , construct validity , programming language , nursing , computer science , patient satisfaction

Integrin alpha(v)beta(3) is expressed by newly formed blood vessels in diseased and neoplastic tissue and can therefore be used as a marker for angiogenesis. We investigated its expression on the vasculature of 40 colon carcinomas using the anti-alpha(v)beta(3)-specific monoclonal antibody LM609. The average relapse-free interval and overall survival in patients suffering from colon carcinomas with high vascular expression of alpha(v)beta(3) integrin was significantly reduced compared with that in patients with low alpha(v)beta(3) integrin expressing tumor vasculature. Moreover, the expression level of alpha(v)beta(3) integrin correlated with the presence of liver metastases. In conclusion, we propose vascular expression of alpha(v)beta(3) integrin as a prognostic indicator for colon carcinoma.

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