Loss of Expression of the PTEN Gene Protein Product Is Associated with Poor Outcome in Breast Cancer | Zendy

Peter L. Depowski | Zendy; Seth I Rosenthal | Zendy; Jeffrey S. Ross | Zendy

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Loss of Expression of the PTEN Gene Protein Product Is Associated with Poor Outcome in Breast Cancer

Author(s) -

Peter L. Depowski,

Seth I Rosenthal,

Jeffrey S. Ross

Publication year - 2001

Publication title -

modern pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.596

H-Index - 153

eISSN - 1530-0285

pISSN - 0893-3952

DOI - 10.1038/modpathol.3880371

Subject(s) - pten , breast cancer , tensin , immunohistochemistry , cancer research , tumor suppressor gene , pathology , medicine , metastasis , estrogen receptor , lymph node , oncology , cancer , biology , carcinogenesis , pi3k/akt/mtor pathway , apoptosis , biochemistry

The PTEN gene, a candidate tumor suppressor, is localized to chromosome 10q23 and shares extensive homology with cytoskeletal proteins auxilin and tensin. A high frequency of mutations at the PTEN locus has been described in a variety of neoplasms including breast cancer. However, the role of PTEN alternations and its association with outcome variables in breast neoplasia is not well established.

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