Open AccessAberrant expression of CHFR in malignant peripheral nerve sheath tumors
Author(s) -
Chikashi Kobayashi,
Yoshinao Oda,
Tomonari Takahira,
Teiyu Izumi,
Kenichi Kawaguchi,
Hidetaka Yamamoto,
Sadafumi Tamiya,
Tomomi Yamada,
Yukihide Iwamoto,
Masazumi Tsuneyoshi
Publication year - 2006
Publication title -
modern pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.596
H-Index - 153
eISSN - 1530-0285
pISSN - 0893-3952
DOI - 10.1038/modpathol.3800548
Subject(s) - mitosis , chromosome instability , spindle checkpoint , aneuploidy , biology , spindle apparatus , pathology , immunohistochemistry , mitotic index , cancer research , genome instability , medicine , microbiology and biotechnology , cell , chromosome , cell division , dna damage , genetics , dna , gene
Mitotic checkpoint maintains genomic integrity before mitosis. Numerous observations have suggested that mitotic abnormalities produce chromosomal instability and aneuploidy. In MPNST, complex karyotypes showing numerical and structural aberrations have been described. 'Checkpoint with forkhead-associated domain and ring finger' (CHFR) was recently identified as defining a new early mitotic checkpoint. We examined the expression of CHFR in 96 cases of MPNST by immunohistochemical and molecular methods. We found reduced (score, < or = 3) expression of CHFR in 63 out of 96 (66%) cases of MPNST, and such alteration was significantly correlated with a high mitotic count, a high Ki-67-labeling index, and a poor prognosis. In addition, MPNST with normal karyotype showed a strong (score, =5) expression of CHFR. Our results support the assertion that CHFR functions as an inhibitor of tumor proliferation.
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