Molecular genetics of human prostate cancer | Zendy

Mark A. Rubin | Zendy; Angelo M. De Marzo | Zendy

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Molecular genetics of human prostate cancer

Author(s) -

Mark A. Rubin,

Angelo M. De Marzo

Publication year - 2004

Publication title -

modern pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.596

H-Index - 153

eISSN - 1530-0285

pISSN - 0893-3952

DOI - 10.1038/modpathol.3800051

Subject(s) - prostate cancer , cancer , prostate , biology , molecular genetics , gene , genetic linkage , genetics , medicine , oncology , pathology

Multiple factors contribute to the high incidence and prevalence of prostate cancer including race, ethnicity, diet, environment, widespread awareness through prostate-specific antigen screening and genetics. Linkage analysis has identified several candidate sites for hereditary prostate cancer gene loci. Molecular studies have also identified genes that are frequently altered in sporadic prostate cancer. It appears that due to the heterogeneity of prostate cancer, multiple genes may be involved in the neoplastic process.

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