Molecular analysis of thyroid tumors | Zendy

Yuri E. Nikiforov | Zendy

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Molecular analysis of thyroid tumors

Author(s) -

Yuri E. Nikiforov

Publication year - 2011

Publication title -

modern pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.596

H-Index - 153

eISSN - 1530-0285

pISSN - 0893-3952

DOI - 10.1038/modpathol.2010.167

Subject(s) - thyroid cancer , thyroid , pathology , medicine , thyroid tumors , molecular pathology , risk stratification , surgical pathology , thyroid nodules , biology , gene , biochemistry

In the recent years, a large number of molecular alterations in thyroid cancer has been discovered and characterized. Some of these markers may have significant diagnostic utility, can be used for tumor prognostication, and serve as potential therapeutic targets. The diagnostic utility of these markers is of particular importance in thyroid fine-needle aspiration samples. Some molecular markers, such as BRAF, offer help in risk stratification and can be potentially used to optimize surgical and postsurgical management of patients with thyroid cancer. This review discusses major molecular alterations known to occur in thyroid cancer, focusing on those markers that have been extensively characterized, carry clinical significance, and are being introduced into pathology practice.

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