Macrophages and control of granulomatous inflammation in tuberculosis | Zendy

JoAnne L. Flynn | Zendy; John Chan | Zendy; Philana Ling Lin | Zendy

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Macrophages and control of granulomatous inflammation in tuberculosis

Author(s) -

JoAnne L. Flynn,

John Chan,

Philana Ling Lin

Publication year - 2011

Publication title -

mucosal immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.596

H-Index - 101

eISSN - 1935-3456

pISSN - 1933-0219

DOI - 10.1038/mi.2011.14

Subject(s) - inflammation , tuberculosis , granuloma , immune system , macrophage , mycobacterium tuberculosis , immunology , granulomatous inflammation , immunity , granuloma formation , biology , medicine , pathology , biochemistry , in vitro

The granuloma that forms in response to Mycobacterium tuberculosis must be carefully balanced in terms of immune responses to provide sufficient immune cell activation to inhibit the growth of the bacilli, yet modulate the inflammation to prevent pathology. There are likely many scenarios by which this balance can be reached, given the complexity of the immune responses induced by M. tuberculosis. In this review, we focus on the key role of the macrophage in balancing inflammation in the granuloma.

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