Molecular mechanisms regulating TGF-β-induced Foxp3 expression | Zendy

Li Xu | Zendy; Atsushi Kitani | Zendy; W Strober | Zendy

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Molecular mechanisms regulating TGF-β-induced Foxp3 expression

Author(s) -

Li Xu,

Atsushi Kitani,

W Strober

Publication year - 2010

Publication title -

mucosal immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.596

H-Index - 101

eISSN - 1935-3456

pISSN - 1933-0219

DOI - 10.1038/mi.2010.7

Subject(s) - foxp3 , transforming growth factor , immune system , biology , transforming growth factor beta , expression (computer science) , immunology , antigen , microbiology and biotechnology , computer science , programming language

Molecular mechanisms regulating transforming growth factor-beta (TGF-beta) induction of Foxp3 (forkhead box P3) expression and thus induction of induced regulatory T cells (Tregs) have been the focus of a great deal of study in recent years. It has become clear that this process is influenced by a number of factors as perhaps might be predicted by the fact that there is an overarching need of the immune system to finetune response to environmental antigens. In this review we discuss these mechanisms, with the aim of presenting a broad picture of how the various observations fit together to form an integrated regulatory regime.

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