Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa | Zendy

Shabaana A. Khader | Zendy; Sarah L. Gaffen | Zendy; Jay K. Kolls | Zendy

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Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa

Author(s) -

Shabaana A. Khader,

Sarah L. Gaffen,

Jay K. Kolls

Publication year - 2009

Publication title -

mucosal immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.596

H-Index - 101

eISSN - 1935-3456

pISSN - 1933-0219

DOI - 10.1038/mi.2009.100

Subject(s) - immunology , biology , immunity , acquired immune system , autoimmunity , effector , innate immune system , innate lymphoid cell , mucosal immunity , lineage (genetic) , interleukin 17 , immune system , gene , genetics

T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role of Th17 cells in autoimmunity is well documented, there is growing evidence that the Th17 lineage and other interleukin (IL)-17-producing cells are critical for host defense against bacterial, fungal, and viral infections at mucosal surfaces. Here we summarize recent progress in our understanding of the function of IL-17-producing cells as a bridge between innate and adaptive immunity against infectious diseases at the mucosa.

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